Loading dose: 10 g (50 mL) in 150 mL diluent total volume: 200 mL.Maintenance Dose: 5.5 g (28 mL) in 82 mL diluent total volume: 110 mL.Loading dose: 11 g (55 mL) in 165 mL in diluent total volume: 220 mL.Maintenance Dose: 6.5 g (33 mL) in 97 mL diluent total volume: 130 mL.Loading dose: 13 g (65 mL) in 195 mL diluent total volume: 260 mL.Maintenance Dose: 7 g (35 mL) in 105 mL diluent total volume: 140 mL.Loading dose: 14 g (70 mL) in 210 mL diluent total volume: 280 mL.Maintenance Dose: 7.5 g (37 mL) in 113 mL diluent total volume: 150 mL.Loading dose: 15 g (75 mL) in 225 mL diluent total volume: 300 mL.Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels.140 mg/kg body weight, orally, once as a loading dose.įor children there is a diluent added to the NAC so that there is no electrolyte and volume complications. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. Give NAC until LFTs improve (not until APAP level is 0) Almost 100% effective if given 24 hr post-ingestion, even with fulminant hepatic failure.Third dose: 100mg/kg in 500 mL D5W over 16hr.Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr.Loading dose: 150mg/kg in 100 mL D5W over 60min.70 mg/kg PO q4hr x17 doses additional dilute to 5% soln.Less preferred than IV route due to unpleasant taste and smell.NAC helps to replete glutathione reserves in the liver, which helps the liver prevent damage from the hepatotoxic NAPQI metabolite. When acetaminophen is taken in large doses, a toxic metabolite N-acetyl-pbenzoquinone imine (NAPQI) accumulates in the body. It can also be used as a nebulized medication to help loosen thick pulmonary sections. Acetylcysteine, or N-acetylcysteine (NAC), is a medication that is used to treat acetaminophen overdose.

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